I was wonder is anyone has the same issue? It seems to me that the newest patch has conflict with some mods but I don't know which one exactly. Either start from Fallout 4 launcher or F4SE won't resolve this problem.
Edited: If you are getting CTD like I do, the possible explanation is that you are using the mods with its own extended script, the newest update will conflict with it. There seems no way working around until Bethesda fix it.