Mods, mods and more mods. Modding Fallout has kept F03 and NV as regularly played games in my Steam Library to this day. Anything from a single weapon or gameplay change to a big overhaul or pack always makes the game more enjoyable.

Besides the obvious, I do different play styles quite a bit now. Siding NCR/Legion, melee only, energy weapons only etc... can really spice up the game and challenges me to play differently than I may want to normally.

Mods Mods Mods. That's the key.

Mostly modding but also i find role-playing is what keeps me intrested in the games, most of the time.

Download certain mods you've never thought of using, try taking out fast travel, download some quest mods, new companions, new lands. My personal favorites: New Vegas bounties 1/2, Wartrash, and project brazil.

Gotta agree with most folks here. Modding and roleplaying keeps me goin'. Sometimes I'll use multiple saves and have branches of different choices with the same PC just to see where things will take me.

At first I try to play every aspect of the game, and once I complete everything I usually go with mods.

I lately downloaded the fnv dust mod. It changes the whole game world. It plays 20 after new vegas. And most major factions have been destroyed or likewise. It changes the world in that most parts that were inhabted before are now abandoned or similar. I think that this mod combined with awop and some other fiting mods makes for a really new/alternative playtrough

Yes, too many of my friends are doing it. When I have such a problem occurs, I just have a rest from the game, switch to something else. And when you want to play again, I set myself the goal is to make your story that way as I want.

Well besides the endless sea of mods, I've been playing on hardcore mode. Which has been pretty fun, I like the the features that it comes with like making sure you have enough water or food on you at all times, enemies do more damage and ammo has weight. Makes me feel like I'm really trying to survive in the wastelands.

When I get bored I would usually do what everyone else said but Now I create custom armors and weapons to implement into the game then I use them in a playthrough.

I don't use fast travel option no matter happens. It's best way to explore wasteland.

I'm with you on that option friend. I mostly wander the wasteland by foot but if it's really far like goodsprings to new vegas i'll have to fast travel wouldn't you?

Install new mods of all kinds. Or just start a new game and role-play.

To keep the game interesting for me is to make new playthroughs with different characters.
And I would always give them a backstory before the game starts. :p

Good Thread

Hardly ill start a new game

Just walking around whitout the fast travel 1 handgun and 1 rifle, a bunch of mod and dogmeat from TTW

Download a new mod and try to find it. Walk around killing raiders as you get to your destination. Another thing I did was speed run through the campaign sort of, or whatever was left of it after I wiped out New Vegas. Execute people you would usually spare. For example, I hit The King with a tranq and made him watch me wipe out his pals. Then I ate them. After, I took his clothes and danced over him before I clubbed him with a 9 iron. Reminiscent of bioshock, in a way.

All sorts of things.
Play differently, use different weapons. RP.
Oh, the mods do help a ton though.

Play on Very Hard, Use mods that kill you very easily...Usually the by the time I die that competitive side in me comes out so that I will win and wont run from the fights in the game, mostly out of spite of the the idea that THE LEGION KILLED ME! THE LEGION! THEY WEAR SKIRTS AND KICK PUPPIES! oh, no, I can not lose to them...

There are a few things that I feel are necessary to keep Bethesda-styled RPGs fresh and interesting in subsequent play-throughs: role-playing, new content, and restraint.

Typically before I start a new play-through of New Vegas or TESV I plan out my character's role first. A new character is usually, but not always, the reason I begin a new play-through in the first place. I fill out a character sheet of sorts in which I describe various aspects of my character's personality and back story. I tend to mold these traits around mechanics I know exist within the game and those added into the game by mods. Also, I tend to find that making the game as realistic as possible (in terms of game mechanics) is conducive to keeping role-playing interesting for me. A decent example of role-play is Gopher's let's plays of New Vegas and Skyrim. He makes all of his in-game decisions based on what his character would do in that situation. Even if that means something bad happens. If you are a mechanics-focused player, you could instead design challenges or participate in speed runs to keep things interesting. The latter suggestion goes against my final point, but if you are into that sort of thing I doubt the last point will matter much to you anyway.

When it comes to finding new content to use in a play-through, I usually look for stuff that will fit the character I have in mind. This typically comes in the form of weapons and armor, but sometimes it can be new game mechanics. After I've picked a new character, I like to go to the nexus and look through all of the new mods that some of my favorite authors have published since my last play-through. Of course, I also look for mods from other authors that would fit the character I have picked. New areas and quests are also a good way to keep things interesting, but I personally find user-created quests don't tend to fit the tone set by Bethesda and Obsidian.

Finally, perhaps the most important thing to keeping these games interesting is showing a bit of restraint. If you feel like you are losing interest in these games, perhaps it's time to take a short break. By playing these games too much without any downtime between sessions, you run the risk of burning yourself out. Play something else for a few months. If you are anything like me, you probably have a huge backlog of games that you haven't even touched yet (who knows, maybe some of those games will give you new ideas for characters). Over the years I have learned that variety is key to preventing burnout. I switch between genres (both aesthetic and mechanics-based) so that I never get too focused on one type of experience and lose interest overall. There used to be a time where I liked playing MMORPGs and FPS, but I played them in excess. I'm only now just getting back into shooters (old school only though), and I don't know if I'll ever be able to play an MMO ever again.

The tl;dr version of my mini-essay: switch things up, look for new content, and don't overdo it.

I use mods as well as limit my usage of VATS.