My favorite weapon has to be the Pancor Jackhammer from Fallout 2.
Whats not to like about a weapon that's powerful and looks cool to boot?

I'd have to say Rock-it Launcher - the fact that it can use practically anything as ammo is amazing and fun!

Police Pistol, because it gives me that whole 1950's Noir detective feeling.

Annabelle, because who doesn't love a big ass explosion?

Survivalist Rifle, because who doesn't love a cool ass modified service rifle with a cooler sound and a backstory?

Tie between these two.

1911 in Honest Hearts, it's classy, and pretty decent.

Anti material because of explosive ammo and it is very powerful.

The Gauss Rifle since every hit counts and it's satisfying to get that kill.

I'd have to choose the Pulse Gun.

I'm just entranced by its smooth, wavy, oceanic blue projectile.   

Tesvixen wrote:

I'd have to say Rock-it Launcher - the fact that it can use practically anything as ammo is amazing and fun!

This. So much this. I'm usually sure to load it with only one type of item at a time (usually teddy bears) and it's honestly not an ineffective weapon as far as mid range combat is concerned.

A close second is the railway rifle. You can pin people's heads and limbs to walls. What's not to love?

I love the original fallout 1 unique plasma gun, The Smitty Special! It is an amazing gun and is my go-to weapon.

fallout 3 had the combat shotgun it was my all time favorite!

I don't know why but before modding Fallout 3 I always adored the Chinese Assault Rifle and then when the Weapon Mod Kits mod came I loved it even more!

When I think about it I have a LOT of mod added weapons, however I'm just going to ignore all of those.

Rockets Red Glare (surpringly to me actually) I'd say is my favourite. I'm not usually a big explosives user but that weapon is just soooo much fun to use. Add to that it looks freaking wicked and comes with the full compliment of three mods and you have a winner!

Mine has to be Vengeance From fallout three, It's such a monster!

Gauss baby! All the way!!!

Vindicator. Although 4.7 caseless rounds are very hard to come by, but its' firepower worth it.
This beautiful and deadly baby once let me kill Frank Horrigan without any Enclave soldiers and gun turrets fire support. Powerful to kill a super mutant with power armor, what's not to love?

The Power Fist or the Deathclaw Gauntlet   

The AER14 prototype definitely!

my favorite fallout weapon,

it would have to be the chinese assault rifle i always used it and it never failed me when i needed somthing killed

JSev33 wrote:

A close second is the railway rifle. You can pin people's heads and limbs to walls. What's not to love?

The Graal and Kishock Harpoon Rifle I've ported for my mod both do this as well.