Any mods you guys can recommend?

Guns, armor, quests. Doesn't really matter just looking for something to spice up the new play through.

Not sure if you already have this or not, but 'Take Cover' can really change up the game. It makes you feel tactical and creates a realistic element.

Other than that, if you're planning on doing a minutemen play through then you should download 'militarised minutemen'. It actually makes the minutemen a formidable faction and works in conjunction with mods such as 'we are the minutemen'.

One of my personal favorites to bring along would be the Beast Master mod.

I've always had it, but I believe the best you can get in vanilla in terms of taming animals is for them to wander around settlements and act as defense. Beast Master give's you a few options by allowing them to be companions, including the ability to personalize them to an extent.
And if you're inclined to do so, you can pair Deathclaw Armory to any Deathclaw's you tame.

And then there's the Nightstalker Dogmeat mod. I do enjoy that one, but it's up to taste there.

well mostly I'm currently contemplating another Fallout 4 playthrough or a New Vegas playthrough.

I just finished a FO4 playthrough a while ago but I saw that Misriah Armory was released and am debating on replaying it just for that.

The thing is that I already have FO4 installed, so if I want to do New Vegas I would have to reinstall the game, Download a couple hundred mods that I like/need, and then reinstall it all.

I'm conflicted....

I haven't played New Vegas in a long time, so I can't give many suggestions on mods for that game.
I've been in that spot before though, it usually nags at me until I make time to do a mod hunt. It's how I found GUN actually.

I'd throw a vote for New Vegas, maybe grab a couple mods that mix things up a bit. Perhaps make the combat more like FO4's or the Better Locational Damage mod if any mods like those exist.
If you do stick with FO4, I believe the Enclave UNSC replacer uses the Misriah weapons and has FCOM support. Maybe that suits your taste? I've never used any of the Enclave mods so you'd be better off checking for yourself.

Tales from the commonwealth definitely adds many quality quests and NPCs, it is created by same user responsible for 3DNPCs for Skyrim, so you can imagine.

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I definitely recommend Sim Settlements. It greatly overhauls the settlement building mechanic in the game that it feels very different.

It also helps with immersing yourself that you are helping build a settlement instead of just making buildings like in Minecraft.

Yeah, from what I've seen, tales from the commonwealth slots into the game like it was always meant to be there.
Sim settlements is great, especially with all the addons -- to varying degrees, your settlers can build their own personal houses and businesses (sometimes to almost comical effect) or even the entire settlement if you allow it.
A (apparently) very controversial choice, but I also use horizon as a major difficulty and survival overhaul. It's a lot harder to find valuables like food, etc. But it's not for people who are satisfied or challenged with the vanilla difficulty and survival elements. Being a huge overhaul, it doesn't mix well with most other mods without a patch.

One of my favorite playthroughs of FO4 was playing as a synth version of Deadpool with wappedell's deadpool armor mod. I honestly used the cheat terminal to overpower my character at the beginning since he's supposed to be a synth who has the powers of deadpool (infinite regeneration).. It would only make sense to extremely powerful right from the beginning.. I also kind of hated the grind of leveling after playing through FO4 so many times.... The synth part also makes sense since its very possible that the player character is a synth.... Just a suggestion!

Also, picking the Sarcastic option every single time goes very well with the Deadpool playthrough.

Weapon mod wise I would recommend FX0x01's weapons like the ru556 or robersonb1's. Player homes I would recommend are elianora's or optionally redrockettv has some pretty good ones as well that are settlement based. Lastly, I would recommend Heather Casdin as she is a very good f4 follower .

I haven't started my next playthrough yet, so I haven't tested them, but Depravity and Project Valkyrie add a lot of content for evil characters, and open up a lot of potential ending combinations.

@Sirdanest Some guys we're trying to get a community playthrough going for FO4, you should check it out if you intend on playing soon