My NVSR .ini file settings which fixed the windows 10 crashing issue and now runs stable and fairly smooth with only the occasional stutter.
My game is heavily modded (FOOK-PN-WMX-WME-EVE-AWOP Convergence, Warzones, IWS, MoMod, Factions Reloaded, 2K textures, etc, etc)
Hope this might help someone suffering crashes like I was before I made the changes. Mainly changed the Critical Sections iDefaultMode to 1.
My Specs: i7 7700k - GTX 1080ti - 16GB RAM - 500GB SSD

First you'll need: New Vegas Script Extender, New Vegas Anti Crash, RoyBatty's 4GB Patch, and enboost, and setting the enblocal.ini to look like:

Steam\steamapps\common\Fallout new vegas\enblocal.ini :

[MEMORY]
ExpandSystemMemoryX64=true
ReduceSystemMemoryUsage=true
DisableDriverMemoryManager=false
DisablePreloadToVRAM=false
EnableUnsafeMemoryHacks=true
ReservedMemorySizeMb=1024
VideoMemorySizeMb=10240
EnableCompression=true
AutodetectVideoMemorySize=false

To use ENBooost without having to turn off Anti Aliasing add this to the bottom of your enblocal.ini file:

[GLOBAL]
UseENBoostWithoutGraphics=true

And also using the Sheson memory patch (Google it) in the NVSE .ini file to look like:

steam\steamapps\common\Fallout New Vegas\Data\NVSE\nvse_config.ini :

[Memory]
DefaultHeapInitialAllocMB=496
scrapheapsizeMB=256

And finally, I am using BOTH the Sheson Memory patch heap replacement as shown above, together with the NVSR heap replacement.
I don't know why it works, but if I only use one or the other I still get crashes around Primm, West Vegas, and other over-modded areas.

steam\steamapps\common\Fallout New Vegas\Data\NVSE\Plugins\sr_New_Vegas_Stutter_Remover.ini :

Master = {
_comment = You can turn on or off each distinct feature from here.
bManageFPS = 1
bHookCriticalSections = 1
bHookLightCriticalSections = 0
bHookHashtables = 1
bReplaceHeap = 1
bReplaceGetTickCount = 1
bLogToConsole = 0
bFastExit = 1
bFlushLog = 1
iSchedulingResolution = 1
bReplaceRandom = 1
bExperimentalStuff = 0
iMainHookPoint = 1
}
Experimental = {
_comment =bReduceSleep and iThreadsFixedToCPUs can probably reasonably be used at 1. > 1 is a bad idea atm.
_comment =other settings here you're probably better off not touching
bReduceSleep = 0
iThreadsFixedToCPUs = 1
bSuppressRandomSeeding = 0
bBenchmarkHeap = 0
bAlternateHeapHooks = 0
iHeapMainBlockAddress = 0
}
FPS_Management = {
_comment =Absent a good reason otherwise, bInject_iFPSClamp=1, fMaximumFPS= 30 to 85 (or 0), fMinimumFPS= 10 to 20, iFPS_Report_Period = 2000 to 60000, fExtraSleepPercent = 0.0 to 0.2
bInject_iFPSClamp = 1
fMaximumFPS = 59
fMinimumFPS = 15
iFPS_Report_Period = 15000
fExtraSleepPercent =0.05
}
GetTickCount = {
_comment =This section is disabled by default - see Master/bReplaceGetTickCount
bForceResolution = 1
bPreserveDC_Bias = 1
bPreserveHighFreqComponents = 0
bForceSync = 0
iSyncLimitMilliseconds = 50
}
CriticalSections = {
_comment = CS stuff helps Oblivion, Fallout, and New Vegas significantly
_comment = much of the benefit comes from the Renderer+0x180 suppression (see overrides below)
_comment = modes: 1=vanilla, 2=fair, 3=staggering(hybrid of 1 & 2), 5=suppressed
bUseOverrides = 1
iDefaultMode = 1
iDefaultSpin = 1000
iStaggerLevel = 5
bEnableMessages = 1
bEnableProfiling = 0
}
LightCriticalSections = {
_comment =LCS stuff is like CS stuff, but with a Bethesda implementation. And inlined sometimes, so difficult for me to work with
bEnableProfiling = 0
bEnableMessages = 1
iDefaultMode = 3
iDefaultSpin = 1000
iStaggerLevel = 5
bFullHooks = 0
bUseOverrides = 0
}
Heap = {
_comment =This section is disabled by default - see Master/bReplaceHeap
_comment =I recommend enabling it however.
_comment = Heap replacement can produce MAJOR improvements in performance on Oblivion at a significant cost in stability
_comment = It crashes instantly on Fallout3 last I remember checking
_comment = It seems to work on Fallout: New Vegas ?
_comment = Algorithms: 1=FastMM4, 2=Microsoft (slow on XP), 3=SimpleHeap1, 4=TBBMalloc, 5=ThreadHeap2, 6=ThreadHeap3, 8=tcmalloc
_comment = Algorithms numbers 1, 4, and 8 require external DLL files in the Data/OBSE/Plugins/ComponentDLLs folder
_comment = Size is in units of megabytes, and only effects algorithms 3, 5, and 6 (other algorithms dynamically determine their own size)
iHeapAlgorithm = 6
bEnableProfiling = 0
iHeapSize = 256
bEnableMessages = 0
bZeroAllocations = 0