mmm seems like something i did have in the past try this setting in the ini file
[BackgroundLoad]
bSelectivePurgeUnusedOnFastTravel=1
[General]
bPreemptivelyUnloadCells=1
if you use fallout new vegas script extender, just create a ini file in the data/NVSE
named nvse_config.ini
and put this one
[Memory]
DefaultHeapInitialAllocMB=400
maybe this will help
ps you can give more MB to Heap depends on the ram usually is ok 400 even if you'r rig can be even more
pss: can you post you'r enb ini file just to be sure of something elese
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