TTW is more of an addon for NV. Most NV mods work for TTW. TTW just added 3 onto it so unless your mods mess with files from 3 or occupy the same stuff, there shouldn't be a problem. I believe texture mods and ENBs are safe to use, but I haven't test them(aside from weapon retextures which are very safe). As for the "are my old saves safe?" I am not too sure. The way TTW works is that when you start off, you are in FO3. To get to NV, you have to get to the train station and fix up the train. If you load a save that was made before you installed the mod, I think things would get screwy. Most big mods suggest you do a new file if you install them so less errors can occur.