Well, some update should be in order.

First of all, Project Nevada really caused problems with GoodSprings. They tried to fix it, but I beleive it has something to do with general compability with start location scripts\npc\activators... I had alot of problems with Goodsprings, most of them were isolated there. And disabling project Nevada also removed crashes. Correct BOSS load order and carefull mod selection will reduce a chance for crashes dramatically.

Just use the newest versions and compability patches, this should fix problems 80%.

I actually prefer to fight for each character to the death, so I`m trying to fix problems by fixing mods, not by starting a new game. Its like to fix a driver issue by reinstalling windows =)

currently having the same problem only difference is it's not P.N. that's causing the freezing on good springs. instead it was a house mod that caused my game to  break.