(This means anything you used in Fallout 3, as well as Fallout: New Vegas)

Anything goes, there's no wrong answers. I'm just curious as to what your general play styles are.
Things like charging in like a mindless melee brute, or picking them off from a distance 1st Recon style.

My answer(to my own question) will definitely be Medicine Stick in Fallout New Vegas. Reason? Versatility in a small yet outrageously deadly and fun package with a fairly balanced reload time. If you mag(tube)dump your Brush Gun against a deathclaw with reckless abandon, they'll make you regret it. The rifle required patience, much like Paciencia.(hence the name) Not to mention the .45-70 cartridge was a force to be reckoned with, regardless of who's guts you were pumping with lead.

My go-to weapon in Fallout 3, would definitely have to be the Blackhawk, or Lincoln's Repeater. Something about those .44's tickled my fancy, and not to mention how beautifully well textured and animated the Model 29(.44 revolver) was in Fallout 3, considering how old that game is.

F3 was paulsons revolver
NV is tough but my most used is probally the leaver action shotgun its just fun

Lucky and the Blackhawk. Revolvers are where it's at.

Trying to pick up an antique Colt double action revolver IRL.

For FO3 I mostly ended up using the Chinese Assault Rifle and the Lincoln Repeater.

As for NV my main goal always was getting a Ranger Sequoia and the Anti Materiel Rifle.

That is when I don't have modded weapons installed :p, I usually go for the weapon that does a lot of damage and isn't way to heavy.

For both of the games my go to weapon would be the hunting rifle cause it was easy to find, has a lot of good mods for it in new vegas and uses a easily findable ammunition. And a lot of super mutant used it so not very hard to find.

My FNV go to weapons are ratslayer for my main and for the secondary is a ranger sequoia

My favorite weapon would be That Gun!

A light shining in darkness, because i love the look and power of it.

I use sledgehammer and a Combat Shotgun but I mix it up so some times a use a knife and a Hunting Rifle, depends how I feel and how much ammo I have left...but most of time I just tend to keep 2 different type of guns and one melee weapon in my inventory