It is hard to say on which one I would pick for the discussion because on one side the Mojave gives the game a more of the post-apocalyptic feel to it with its barrenness. But on the other hand the Commonwealth giving it a Zombie Movie feel with all of the abandoned building and homes with a percentage of them having some form of creature in it. So for me its hard to say but I believe they both fit the Fallout World.

This sounds like it was meant to be a reply to a fallout new vegas vs fallout 4 topic?

yeah I think this was meant for that